What issues do you have focusing on your most important life goals?

@chrisbrogan was asking how to focus on life goals. Is this an issue you have, too? How come? What gets in the way?

It seems to me two important aspects to focusing your life on your goals are:

1. Know what your goals are.
2. Say ‘No’ to time uses that aren’t aligned with those goals.

What are your obstacles? How have you overcome them? (Or if not, what’s gone wrong?)